The Bayrer Lab and our collaborators publish our work in a variety of academic journals including Cell, Nature Communications, Journal of Neuroscience, and Proceedings of the National Academy of Sciences.
Mechanims of Intestinal Homeostasis and Repair
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
Man K, Bowman C, Braverman KN, Escalante V, Tian Y, Bisanz JE, Ganeshan K, Wang B, Patterson A, Bayrer JR, Turnbaugh PJ, Chawla A.
Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32029-32037. PMID: 33257580
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA.
Nat Commun. 2018 Oct 10;9(1):4055. doi: 10.1038/s41467-018-06137-w. PMID: 30305617
Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology.
Wallach TE, Bayrer JR. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):180-185. doi: 10.1097/MPG.0000000000001411. Review. PMID: 27632431
Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ.
Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2467-72. doi: 10.1073/pnas.1500978112. Epub 2015 Feb 9. PMID: 25675535
Gut-Brain Axis
Gut Enterochromaffin Cells are Critical Drivers of Visceral Pain and Anxiety
Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, Brierley SM, Julius D. Nature. 2023 Apr;616(7955):137-142. doi: 10.1038/s41586-023-05829-8. Epub 2023 Mar 22. PMID: 36949192
Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease.
Kulkarni S, Ganz J, Bayrer J, Becker L, Bogunovic M, Rao M.
J Neurosci. 2018 Oct 31;38(44):9346-9354. doi: 10.1523/JNEUROSCI.1663-18.2018. PMID: 30381426
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.
Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D.
Cell. 2017 Jun 29;170(1):185-198.e16. doi: 10.1016/j.cell.2017.05.034. Epub 2017 Jun 22. PMID: 28648659
Extra-Intestinal Collaborative Studies
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA.
Nat Commun. 2019 Jan 11;10(1):163. doi: 10.1038/s41467-018-08046-4. PMID: 30635563